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Lipid hypothesis : ウィキペディア英語版 | Lipid hypothesis The lipid hypothesis is a medical idea regarding a link between blood cholesterol levels and occurrence of heart disease. A summary from 1976 described it as "measures used to lower the plasma lipids in patients with hyperlipidemia will lead to reductions in new events of coronary heart disease". Another formulation is that "decreasing blood cholesterol... significantly reduces coronary heart disease events"; this discussion is also referred to as the "cholesterol controversy". It is closely related to the saturated fat and cardiovascular disease controversy. An accumulation of evidence has led to the acceptance of the lipid hypothesis by most of the medical community; however, a minority contends that the evidence does not support it, and that mechanisms independent of blood cholesterol levels are responsible.〔 ==Ideas to the mid-20th century== The German pathologist Rudolf Virchow described lipid (medical term for fat molecules) accumulation in arterial walls. In 1913, a study by Nikolai Anitschkow showed that rabbits fed on cholesterol developed lesions in their arteries similar to atherosclerosis, suggesting a role for cholesterol in atherogenesis. By 1951, it was accepted that, although the causes of atheroma were still unknown, fat deposition was a major feature of the disease process. "The so-called fatty flecks or streaks of arteries are the early lesions of atherosclerosis and... may develop into the more advanced lesions of the disease.
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